A drone attack on a small US outpost in Jordan has left three American service members dead and at least 25 others injured.

The attack took place at Tower 22 in Jordan near the border with Syria on Sunday, marking the first US troops to have been killed in the region since the beginning of the Gaza war in early October.

In a statement, the US Central Command (CENTCOM) confirmed that three American soldiers were killed and 25 injured in a one-way drone attack that “impacted at a base in northeast Jordan.”

"On January 28, three US service members were killed and 25 injured from a one-way attack UAS that impacted at a base in northeast Jordan, near the Syria border. 

The CENTCOM said, in accordance with DoD policy, the identities of the service members will be withheld until 24 hours after their next of kin have been notified.

A US official told Reuters news agency that at least 34 service members were being examined for possible traumatic brain injury.

The Islamic Resistance in Iraq released a statement claiming responsibility for the drone attack on Al-Tanf base at the Syria-Jordan border.

In December, US officials said that military bases housing American troops in Iraq and Syria had been attacked at least 97 times since October 17.